In an article for MIT Technology Review, Antonio Regalado reports that researchers in Shenzhen, led by He Jiankui, are recruiting couples for a study to produce the first genetically edited human babies. They are hoping to use the CRISPR gene editing technique to “eliminate a gene called CCR5 in hopes of rendering the offspring resistant to HIV, smallpox, and cholera”.
The birth of the first genetically tailored humans would be a stunning medical achievement, for both He and China. But it will prove controversial, too. Where some see a new form of medicine that eliminates genetic disease, others see a slippery slope to enhancements, designer babies, and a new form of eugenics.
“In this ever more competitive global pursuit of applications for gene editing, we hope to be a stand-out,” He and his team wrote in an ethics statement they submitted last year. They predicted their innovation “will surpass” the invention of in vitro fertilization, whose developer was awarded a Nobel Prize in 2010.
A follow-up by the Associated Press indicates that He’s program is already underway and has resulted in a successful birth of twins earlier this month.
Tags: Antonio Regalado CRISPR He Jiankui genetics scienceThe researcher, He Jiankui of Shenzhen, said he altered embryos for seven couples during fertility treatments, with one pregnancy resulting thus far. He said his goal was not to cure or prevent an inherited disease, but to try to bestow a trait that few people naturally have - an ability to resist possible future infection with HIV, the AIDS virus.
He said the parents involved declined to be identified or interviewed, and he would not say where they live or where the work was done.
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